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Synthesis of potent and highly selective inhibitors of human tryptase.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.

The Bristol-Myers Squibb Pharmaceutical Research Institute

The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Synthesis of potent and selective 2-azepanone inhibitors of human tryptase.

The Bristol-Myers Squibb Pharmaceutical Research Institute

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics.

The Bristol-Myers Squibb Pharmaceutical Research Institute